Effects of etodolac on prostaglandin E2 biosynthesis.
نویسندگان
چکیده
منابع مشابه
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis.
Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase (COX) enzymes, and various lineagespecific terminal prostanoid synthases. Prostaglandin E synthase (PGES), which isomerizes COX-derived PGH2 specifically to PGE2, occurs in multiple forms with distinct enzymatic properties, expressions, localizations and functions. Two o...
متن کاملCurcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.
Prostaglandin E(2) (PGE(2)) plays a crucial role in the apparent link between tumor growth and chronic inflammation. Cyclooxygenase (COX)-2 and microsomal PGE(2) synthase-1, which are overexpressed in many cancers, are functionally coupled and thus produce massive PGE(2) in various tumors. Curcumin, a polyphenolic beta-diketone from tumeric with anti-carcinogenic and anti-inflammatory activitie...
متن کاملEffects of prostaglandin E2 on rat skin: inhibition of sterol ester biosynthesis and clearing
Severe scaly lesions in the skin, especially in the were accompanied by growth retardation, impaired feet and tail, of the rat were induced by feeding a diet deficient fertility, increased water consumption, and diminished in essential fatty acids (EFA). Analysis of the fatty acids in skin urine production^ B~~~ and B~~~ proposed that linoleic lipids of these EFA-deficient rats showed a marked ...
متن کاملEBV suppresses prostaglandin E2 biosynthesis in human monocytes.
It is well known that EBV has developed strategies to evade immune surveillance. Previously, EBV was shown to bind specifically to monocytes and regulate expression of proinflammatory mediators such as IL-1, IL-6, TNF-alpha, and leukotrienes. EBV was also found to affect phagocytosis of monocytes. In this study, we show that in addition to these effects, EBV suppresses the biosynthesis of PGE2,...
متن کاملCharacterizing the Effects of Prostaglandin E2 on Tendon Mechanical Properties
Elyse Jeannette Baum Characterizing the Effects of Prostaglandin E 2 on Tendon Mechanical Properties (Under the direction of Paul Weinhold) Tendinopathy is a common clinical problem, both athletically and occupationally. It develops from repetitive mechanical loading of tendon; however the molecular mechanisms are not well understood. It is thought that prostaglandin E 2 (PGE 2) and matrix meta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Ensho
سال: 1995
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.15.409